Jonathan E. Lim, M.D.

Jonathan E. Lim, MD, is a physician-turned-venturepreneur who is dedicated to founding, funding, and leading mission-driven ventures. Jonathan founded City Hill Ventures in December 2010 and serves as Managing Partner, focused on building or helping other health care entrepreneurs build great companies with a transformative impact on patients, the health care industry, and society. Jonathan also serves as Venture Partner at ARCH Venture Partners, one of the largest seed and early stage technology venture firms in the U.S., which he joined in December 2018. In these capacities, Jonathan serves as Executive Chairman of Erasca, which he co-founded in July 2018; as Chairman and Co-founder of Pretzel Therapeutics, which he joined in December 2018; and as Chairman of Optera Therapeutics, which he joined in December 2018.

From 2003 to 2018, Jonathan was a leader and founding investor of four biotechnology startups that delivered novel therapies for the benefit of patients globally, raised a combined $1 billion in capital and generated more than $4 billion of shareholder value. Jonathan’s most recent operational role was serving as Chairman, President, CEO and Co-founder of Ignyta (RXDX), from August 2011 until its acquisition by Roche in February 2018, and overseeing its subsequent integration into Roche and Genentech until July 2018. Previously, he was Chairman and Co-founder of Bonti from August 2015 until its October 2018 acquisition by Allergan; Chairman, CEO and Co-founder of Eclipse Therapeutics from March 2011 to its September 2012 acquisition by Bionomics; and President, CEO and Chairman-then-Director of Halozyme Therapeutics (HALO) from May 2003 to December 2010.

Jonathan also serves as Co-President of City Hill Foundation, which he launched with his wife in December 2011. He is an advisor to nonprofit organizations, including Stanford University, University of California, San Diego, The Scripps Research Institute and UrbanLife. Earlier in his career, Jonathan was a management consulting at McKinsey & Company, an NIH Postdoctoral Fellow at Harvard Medical School and Dana Farber Cancer Institute, and a general surgery resident at New York Hospital-Cornell and Memorial Sloan Kettering Cancer Center. He holds B.S. and M.S. degrees from Stanford University, an M.D. from McGill University, and an M.P.H. from Harvard University.